2025
Zhang, L., Xiao, R., Gao, W., Garcia, J., Pan, X., Daristotle, J. L., Forster, T., Han, J., Chaddah, M., Varshney, D., Menon, N., McHugh, K. J., Pedretti, B. J., Yeo, J. Y., Yang, X., MacDonald, S., Langer, R., Jaklenec, A. (2025). Polyanhydride-Based Microparticles for Programmable Pulsatile Release of Diphtheria Toxoid (DT) for Single-Injection Self-Boosting Vaccines. Advanced Materials, 2501168. https://doi.org/10.1002/adma.202501168
Han J., Kanelli M., Liu Y., Daristotle J., Pardeshi A., Forster T.A., Karchin A., Folk B., Murmann L., Tostanoski L.H., Carrasco S.E., Zhang L., Eshaghi B., Alsaiari S.K., Pyon S., Perkinson C.F., Bawendi M.G., Barouch D.H., Durand F., Langer R., Jaklenec A. Deep Learning-assisted On-patient Medical Record and mRNA Therapeutics Delivery using Microneedles. Nat. Mater. (2025). https://doi.org/10.1038/s41563-024-02115-4.
2024
Zhang, L., Xiao, R., Jin, T., Pan, X., Fransen K.A., Alsaiari S.K., Lau A., He R., Han J., Pedretti B.J., Yeo J.Y., Yang X., Olsen B.D., Alexander-Katz A., Smith Z.P., Langer R., Jaklenec A. Degradable poly(β-amino ester) microparticles for cleansing products and food fortification. Nat Chem Eng (2024). https://doi.org/10.1038/s44286-024-00151-0
Kanelli, M., Bardhan, N.M., Sarmadi, M., Eshaghi, B., Alsaiari, S.K., Rothwell, W.T., Pardeshi, A., Varshney, D., De Fiesta, D. C., Mak, H., Spanoudaki, V., Henning, N., Kumar, A., Han, K., Belcher, A.M., Langer, R., Jaklenec A. A Machine Learning-Optimized System for Pulsatile, Photo- and Chemotherapeutic Treatment Using Near-Infrared Responsive MoS2-Based Microparticles in a Breast Cancer Model. ACS Nano 2024. https://doi.org/10.1021/acsnano.4c07843
Alsaiari, S.K., Eshaghi, B., Du B., Kanelli, M., Li, G., Wu, X., Zhang, L., Chaddah, M., Lau, A., Yang, X., Langer, R., Jaklenec, A. CRISPR–Cas9 delivery strategies for the modulation of immune and non-immune cells. Nat Rev Mater (2024). https://doi.org/10.1038/s41578-024-00725-7
Alsaiari, S.K., Nadeef, S., Daristotle J.L., Rothwell, W., Du, B., Garcia, J., Zhang, L., Sarmadi, M., Forster, T., Menon, N., Lin, S.Q., Tostanoski, L.H., Hachmann, N., Wang, E.Y., Ventura, J.D., Barouch, D.H., Langer, R., Jaklenec, A. Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer. Science Advances10, eadj6380(2024). DOI:10.1126/sciadv.adj6380.
Collins, J., Han, J., Sarmadi, M., Allison-Logan, S., vander Straeten, A., Perkinson C.F., Acolaste, S., Kanelli, M., Daristotle, J., Karchin, A., Henderson, M., Cruz, M., Artzi, D., Alsaiari, S.K., Zhang, L., Levy, L., Wood, L., Jing, L., McHugh, K.J., Bawendi, M.G., Langer, R., Jaklenec A. On-Patient Temporary Medical Record for Accurate, Time-Sensitive Information at the Point of Care. Advanced Functional Materials (2024).
2023
Eshaghi, B., Schudel, A., Sadeghi, I., Chen Z., Lee A.H., Kanelli M., Tierney F., Ingalls B., Francis D.M., Li G., Han J., von Andrian U., Langer R., Jaklenec A. The role of engineered materials in mucosal vaccination strategies. Nature Reviews Materials (2023).
Wang E. Y., Sarmadi M., Ying B., Jaklenec A., Langer R. Recent Advances in Micro- and Nano-scale Carrier Systems for Controlled Delivery of Vaccines. Biomaterials, 2023.
Li Z., Zhang S., Zuber F., Altenried S., Jaklenec A., Langer R., Ren Q. Topical application of Lactobacilli successfully eradicates Pseudomonas aeruginosa biofilms and promotes wound healing in chronic wounds. Microbes and Infection, 2023, p. 105176.
vander Straeten, A., Sarmadi, M., Daristotle, J.L., Kanelli M., Tostanoski L.H., Collins J., Pardeshi A., Han J., Varshney D., Eshaghi B., Garcia J., Forster T.A., Li G., Menon N., Pyon S.L., Zhang L., Jacob-Dolan C., Powers O.C., Hall K., Alsaiari S.K., Wolf M., Tibbitt M.W., Farra R., Barouch D.H., Langer R., Jaklenec A. A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines. Nature Biotechnology (2023).
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2022
Di Z., Lu X., Zhao J., Jaklenec A., Zhao Y., Langer R., Li L. Mild Acidosis-Directed Signal Amplification in Tumor Microenvironment via Spatioselective Recruitment of DNA Amplifiers. Angewandte Chemie (International ed. in English), 61, e202205436, 2022.
Tang, W., Zhuang, J., Anselmo, A.c., Duan, A., Zhang, R., …, Oxley, J., Daristotle, J., Collins, J., Langer, R., Jaklenec, A., 2022., Enhanced stability and clinical absorption of a form of encapsulated vitamin A for food fortification. PNAS. Vol 119, No. 51. e2211534119.
Sarmadi, M., Ta, C., VanLonkhuyzen, A., De Fiesta, D., Kanelli, M., Sadeghi, I., Behrens, A., Ingalls, B., Menon, N., Daristotle, J., Yu, J., Langer, R., Jaklenec, A., 2022., Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles. Science Advances. Vol 8, Issue 28.
Sadeghi, I., Lu, X., Sarmandi, M., Langer, R., and Jaklenec, A., 2022. Micromolding of Thermoplastic Polymers for Direct Fabrication of Discrete, Multilayered Microparticles. Small Methods. 2200232.
2021
Ding, Y., Li, Z., Jaklenec, A., and Hu, Q., 2021. Vaccine delivery systems toward lymph nodes. Advanced Drug Delivery Reviews, 179, p.113914.
Makvandi, P., Jamaledin, R., Chen, G., Baghbantaraghdari, Z., Zare, E.N., di Natale, C., Onesto, V., Vecchione, R., Lee, J., Tay, F.R., Netti, P., Mattoli, V., Jaklenec, A., Gu, Z., and Langer, R., 2021. Stimuli-responsive transdermal microneedle patches. Materials Today, 47, pp. 206-222.
2020
Lu, X., Miao, L., Gao, W., Chen, Z., McHugh, K.J, Sun, Y., Tochka, Z., Tomasic, S., Sadtler, K., Hyacinthe, A., Huang, Y., Graf, T., Hu, Q., Sarmadi, M., Langer, R., Anderson, D.G., and Jaklenec, A., 2020. Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy. Science Translational Medicine,12, eaaz6606.
Abstract. Full text.
Sarmadi, M., Behrens, A.M., McHugh, K.J., Contreras, H.T.M., Tochka, Z.L., Lu, X., Langer, R., Jaklenec, A., 2020. Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations. Science Advances, 6(28).
Langer, R., Jaklenec, A., Traverso, G. and Hartman, D., 2020. From molecule to patient: a biotech perspective. Clinical Pharmacology & Therapeutics, 107(1), pp.65-67.
Yeom, J., Guimaraes, P.P., Ahn, H.M., Jung, B.K., Hu, Q., McHugh, K., Mitchell, M.J., Yun, C.O., Langer, R. and Jaklenec, A., 2020. Chiral Supraparticles for Controllable Nanomedicine.Advanced Materials, 32(1), p.1903878.
Featured by MIT News, Science Daily, PhysOrg, EurekAlert! (AAAS).
2019
McHugh, K.J., Jing, L., Severt, S.Y., Cruz, M., Sarmadi, M., Jayawardena, H.S.N., Perkinson, C.F., Larusson, F., Rose, S., Tomasic, S., Graf, T., Tzeng, S.Y., Sugarman, J.L., Vlasic, D., Peters, M., Peterson, N., Wood, L., Tang, W., Yeom, J., Collins, J., Welkhoff, P.A., Karchin, A., Tse, M., Gao, M., Bawendi, M.G., Langer, R. and Jaklenec, A. 2019. Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination. Science Translational Medicine, 11(523).
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Anselmo, A.C., Xu, X., Buerkli, S., Zeng, Y., Tang, W., McHugh, K.J., Behrens, A.M., Rosenberg, E., Duan, A.R., Sugarman, J.L., Zhuang, J., Collins, J., Lu, X., Graf, T., Tzeng, S.Y., Rose, S., Acolatse, S., Nguyen, T.D., Le, X., Guerra, A.S., Freed, L.E., Weinstock, S.B., Sears, C.B., Nikolic, B., Wood, L., Welkhoff, P.A., Oxley, J.D., Moretti, D., Zimmermann, M.B., Langer, R., and Jaklenec, A. 2019. A heat-stable microparticle platform for oral micronutrient delivery. Science translational medicine, 11(518).
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C. C. Beh, S. Farah, R. Langer, and A. Jaklenec, in Antimicrobial Materials for Biomedical Applications, ed. A. J. Domb, K. R. Kunduru, and S. Farah, The Royal Society of Chemistry, 2019, ch. 12, pp. 325-347.
2018
Li, Z., Behrens, A.M., Ginat, N., Tzeng, S.Y., Lu, X., Sivan, S., Langer, R. and Jaklenec, A., 2018. Biofilm‐Inspired Encapsulation of Probiotics for the Treatment of Complex Infections.Advanced Materials, 30(51), p.1803925.
Featured by MIT News, UPI, EurekAlert! (AAAS).
Glinel, K., Behrens, A., Langer, R.S., Jaklenec, A. and Jonas, A.M., 2018. Nanofibrillar Patches of Commensal Skin Bacteria. Biomacromolecules, 20(1), pp.102-108.
Tzeng, S.Y., McHugh, K.J., Behrens, A.M., Rose, S., Sugarman, J.L., Ferber, S., Langer, R. and Jaklenec, A., 2018. Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response. Proceedings of the National Academy of Sciences, 115(23), pp.E5269-E5278.
Featured by MIT News.
Ferber, S., Behrens, A.M., McHugh, K.J., Rosenberg, E.M., Linehan, A.R., Sugarman, J.L., Jayawardena, H.S.N., Langer, R. and Jaklenec, A., 2018. Evaporative Cooling Hydrogel Packaging for Storing Biologics Outside of the Cold Chain. Advanced healthcare materials, 7(14), p.1800220.
Jonas, A.M., Glinel, K., Behrens, A., Anselmo, A.C., Langer, R.S. and Jaklenec, A., 2018. Controlling the Growth of Staphylococcus epidermidis by Layer-By-Layer Encapsulation. ACS applied materials & interfaces, 10(19), pp.16250-16259.
Kauffman, K.J., Oberli, M.A., Dorkin, J.R., Hurtado, J.E., Kaczmarek, J.C., Bhadani, S., Wyckoff, J., Langer, R., Jaklenec, A. and Anderson, D.G., 2018. Rapid, single-cell analysis and discovery of vectored mRNA transfection in vivo with a loxP-flanked tdTomato reporter mouse. Molecular Therapy-Nucleic Acids, 10, pp.55-63.
McHugh, K.J., Jing, L., Behrens, A.M., Jayawardena, S., Tang, W., Gao, M., Langer, R. and Jaklenec, A., 2018. Biocompatible semiconductor quantum dots as cancer imaging agents. Advanced Materials, 30(18), p.1706356.
Guarecuco, R., Lu, J., McHugh, K.J., Norman, J.J., Thapa, L.S., Lydon, E., Langer, R. and Jaklenec, A., 2018. Immunogenicity of pulsatile-release PLGA microspheres for single-injection vaccination. Vaccine, 36(22), pp.3161-3168.
2017
McHugh, K.J., Nguyen, T.D., Linehan, A.R., Yang, D., Behrens, A.M., Rose, S., Tochka, Z.L., Tzeng, S.Y., Norman, J.J., Anselmo, A.C., Xu, X., Tomasic, S., Taylor, M.A., Lu, J., Guarecuco, R., Langer, R. and Jaklenec, A. 2017. Fabrication of fillable microparticles and other complex 3D microstructures. Science, 357(6356), pp.1138-1142.
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Schoellhammer, C.M., Lauwers, G.Y., Goettel, J.A., Oberli, M.A., Cleveland, C., Park, J.Y., Minahan, D., Chen, Y., Anderson, D.G., Jaklenec, A., Snapper, S.B., Langer, R. and Traverso, G., 2017. Ultrasound-mediated delivery of RNA to colonic mucosa of live mice. Gastroenterology, 152(5), pp.1151-1160.
Oberli, M.A., Reichmuth, A.M., Dorkin, J.R., Mitchell, M.J., Fenton, O.S., Jaklenec, A., Anderson, D.G., Langer, R. and Blankschtein, D., 2017. Lipid nanoparticle assisted mRNA delivery for potent cancer immunotherapy. Nano letters, 17(3), pp.1326-1335.
2016
Oberli M.A., Reichmuth A.M., Dorkin J.R., Mitchell M.J., Fenton O.S., Jaklenec A., Anderson D.G., Langer R., and Blankschtein D. 2016. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Letters, 2017 17 (3), 1326-1335.
Anselmo, A.C., McHugh, K.J., Webster, J., Langer, R. and Jaklenec, A., 2016. Layer‐by‐layer encapsulation of probiotics for delivery to the microbiome.Advanced Materials, 28(43), pp.9486-9490.
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Tzeng, S.Y., Guarecuco, R., McHugh, K.J., Rose, S., Rosenberg, E.M., Zeng, Y., Langer, R. and Jaklenec, A., 2016. Thermostabilization of inactivated polio vaccine in PLGA-based microspheres for pulsatile release.Journal of Controlled Release, 233, pp.101-113.
Chen, X., Wu, B., Jayawardana, K.W., Hao, N., Jayawardena, H.S.N., Langer, R., Jaklenec, A. and Yan, M., 2016. Magnetic multivalent trehalose glycopolymer nanoparticles for the detection of mycobacteria.Advanced healthcare materials, 5(16), pp.2007-2012.
Reichmuth, A.M., Oberli, M.A., Jaklenec, A., Langer, R. and Blankschtein, D., 2016. mRNA vaccine delivery using lipid nanoparticles. Therapeutic delivery, 7(5), pp.319-334.
Jaklenec, A., Anselmo, A.C., Hong, J., Vegas, A.J., Kozminsky, M., Langer, R., Hammond, P.T. and Anderson, D.G., 2016. High throughput layer-by-layer films for extracting film forming parameters and modulating film interactions with cells. ACS applied materials & interfaces, 8(3), pp.2255-2261.
2015
McHugh, K.J., Guarecuco, R., Langer, R. and Jaklenec, A., 2015. Single-injection vaccines: Progress, challenges, and opportunities. Journal of Controlled Release, 219, pp.596-609.
2012
Jaklenec, A., Stamp, A., Deweerd, E., Sherwin, A. and Langer, R., 2012. Progress in the tissue engineering and stem cell industry “are we there yet?”. Tissue Engineering Part B: Reviews, 18(3), pp.155-166.
2008
Jaklenec, A., Hinckfuss, A., Bilgen, B., Ciombor, D.M., Aaron, R. and Mathiowitz, E., 2008. Sequential release of bioactive IGF-I and TGF-β1 from PLGA microsphere-based scaffolds.Biomaterials, 29(10), pp.1518-1525.
Lysaght, M.J., Jaklenec, A. and Deweerd, E., 2008. Great expectations: private sector activity in tissue engineering, regenerative medicine, and stem cell therapeutics. Tissue Engineering Part A, 14(2), pp.305-315.
2007
Jaklenec, A., Wan, E., Murray, M.E. and Mathiowitz, E., 2008. Novel scaffolds fabricated from protein-loaded microspheres for tissue engineering. Biomaterials, 29(2), pp.185-192.
2006
Ciombor, D.M., Jaklenec, A., Liu, A.Z., Thanos, C., Rahman, N., Weston, P., Aaron, R. and Mathiowitz, E., 2006. Encapsulation of BSA using a modified W/O/O emulsion solvent removal method. Journal of microencapsulation, 23(2), pp.183-194.
2003
Fu, K., Harrell, R., Zinski, K., Um, C., Jaklenec, A., Frazier, J., Lotan, N., Burke, P., Klibanov, A.M. and Langer, R., 2003. A potential approach for decreasing the burst effect of protein from PLGA microspheres.Journal of pharmaceutical sciences, 92(8), pp.1582-1591.
See Ana Jaklenec’s publications on Google Scholar.